The genetic mutation can occur when a person has a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. They also lacked the enzyme diaphorase in their red blood cells, normally diaphorase converts methemoglobin back to hemoglobin.

Methemoglobinemia is a blood disorder in which an large amount of methemoglobin (a form of hemoglobin) is produced

Methemoglobin can develop blue skin without any negative symptoms.

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Meet the Fulgates, a family of people with blue skin that lived in Kentucky for many generations. Most of the family members never suffered any health effects and lived into their 80s and 90s. It was discovered that there was inbreeding within the family that contributed to the high number of blue offspring.

Join the conversation! 12 Comments

  1. Interesting. Never knew about that. Who would have thought it was possible? We learn something new every day.

    Liked by 3 people

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  2. The world gets stranger every day.

    Liked by 2 people

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  3. Drinking too much SunnyD can cause your skin to turn yellow, …but that’s a temporary change, not permanent.

    Liked by 2 people

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  4. Green women from Venus might be interesting to meet.

    Liked by 1 person

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  5. Anyone else think of Mystique?

    Liked by 1 person

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